Tools and tips for diagnosing CMV and HLA allele status and annotating repertoire TCRs
IEDB can annotate TCRs with peptide/species associations, but many TCRs appear to be cross-reactive.
Look at pairs of CMV ECOcluster TCRs that differ by one amino acid swap. They’re strongly position-dependent!
Intersect CMV ECOcluster TCRs with repertoires to predict CMV status and HLA type.
A few sets of V and J genes are often confused with each other. We should probably treat them as groups.
The 2026 CMV ECOcluster has twice as many TCRs. What else changed?
Per-HLA-allele clusters in the CMV ECOcluster range widely in diagnostic value. Why?
Download the CMV ECOcluster and have a look. Break down TCRs and HLA-COclusters by HLA allele and class.
